Charles "Weeb" Ewbank was born on May 6, 1907, in Richmond, Indiana, to Mr. and Mrs. Charles Ewbank, and would grow up in the Fairview area of Richmond, the son of a grocery store owner. At nine, Weeb was delivering orders for his father in a horse-drawn wagon. As a teenager, he would find his way to Dayton, Ohio, to watch Jim Thorpe play for the Canton Bulldogs.
At Oliver P. Morton High School, Ewbank was a three-sport star. He married his wife Lucy—whom he would remain married to for sixty-nine years—while still attending high school. In order to earn extra money, he played semi-pro ball. He went on to play football and baseball in college.